![]() They have been effective in people unresponsive to the usual resuscitation methods. There are several brand name lipid emulsion therapies, however Intralipid, a soy-based lipid emulsion that contains long-chain triglycerides, is the most commonly used (Figure 1). Lipid emulsions are effective in treating experimental models of severe cardiotoxicity from intravenous overdose of local anaesthetic drugs such as bupivacaine. Poison Center bupropion fat emulsion lipid emulsion poisoning. Lipid emulsion therapy is an intravenous therapy that binds lipophilic toxins and therefore reverses their toxicity. We report a case of asymptomatic pancreatitis following extended infusion lipid emulsion. Further characterization of the efficacy and complications of ILE in bupropion toxicity is needed. Background: Lipid emulsion is gaining popularity as an antidote for lipophilic drug overdose, and is generally considered safe at doses recommended for antidotal therapy. The high mortality and complication rate after ILE in this study sample does not reflect the positive outcome benefit seen in previous published case reports. Patient complications after ILE administration were common and included continued hypotension in 7 cases, recurrent seizures in 3 patients, ARDS in two patients, and renal failure in one patient. One of the survivors had neurologic sequelae necessitating placement in a long-term care facility. ![]() Of these, four patients expired and five survived. Nine cases of ILE administration were identified. There were 1274 cases of suspected bupropion ingestion reported during the study period with 14 reported deaths. ![]() The administration of lipid emulsions is recommended within 7 days after starting PN (parenteral nutrition) to avoid deficiency of essential fatty acids. Cases in which ILE was administered or death was listed as the outcome were further analyzed. The infusion of lipid emulsions allows a high energy supply, facilitates the prevention of high glucose infusion rates and is indispensable for the supply with essential fatty acids. The objective of this study is to characterize the outcomes of patients with suspected bupropion toxicity in which ILE was administered and the indications for its use.Įlectronic records from one regional poison center were searched for intentional bupropion ingestions from 1 January 2009 through 31 December 2015. ILE is made of neutral, medium to long-chain triglycerides. This recommendation is based largely on published case reports and cases presented at scientific meetings. In addition, lipid emulsions have served as a delivery vehicle for hydrophobic drugs like propofol. Intravenous lipid emulsion (ILE) has been suggested as a treatment by some for the treatment of refractory bupropion toxicity. Bupropion toxicity is characterized by central nervous system and cardiovascular toxicity. Intravenous lipid emulsions are a condensed source of energy and essential fatty acids, providing 9 kcal/g of energy.
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